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Duphaston (Dydrogesterone)

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Duphaston (Dydrogesterone) is an orally active progestogen which acts directly on the uterus producing a complete secretory endometrium in an estrogen-primed uterus.At therapeutic levels dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore Duphaston is non-androgenic non-estrogenic non-corticoid non-anabolic and is not excreted as pregnanediol.

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About Duphaston (Dydrogesterone):

Product Type: Women's Health

Brand name: Duphaston Generic name: Dydrogesterone Common uses Duphaston is an orally active progestogen which acts directly on the uterus producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels Duphaston has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore Duphaston is non-androgenic non-estrogenic non-corticoid non-anabolic and is not excreted as pregnanediol. Before using Irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Combined with an estrogenic substance Duphaston can be applied in secondary amenorrhoea dysfunctional uterine bleeding and post-menopausal complaints where endogenous progesterone deficiency is implicated. Directions In general The dosage schemes below are meant as general recommendations. For optimal therapeutic effect the dosages are to be adapted to the nature and severity of the disorder. In irregular cycles due to endogenous progesterone deficiency Duphaston 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles. In secondary amenorrhoea Administration of Duphaston in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0 05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle and 5 mg Duphaston is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding the same is repeated to imitate a natural cycle. In dysfunctional uterine bleeding The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding. To stop bleeding: Duphaston 10 mg together with 0 10 mg ethinylestradiol twice daily for 5 to 7 days. To prevent heavy bleedings: Duphaston 5 mg twice daily from day 11 to day 25 of the cycle if necessary combined with an estrogen during the first half of the cycle. In post-menopausal complaints If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy — HRT) Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced. If on continuous estrogen therapy: Duphaston 10 mg twice daily during the first 12 to 14 days of each calendar month. If on cyclic estrogen therapy: Duphaston 10 mg twice daily during the last 12 to 14 days of the treatment. Cautions Duphaston should not be given to patients with undiagnosed vaginal bleeding nor to those with a history of thromboembolic disorders. Duphaston should be used with caution in patients with cardiovascular renal or hepatic impairment diabetes mellitus asthma epilepsy and migraine. It should be used with care in persons with a history of mental depression. Store in a dry dark place at temperatures not exceeding 25°C. Keep out of reach of children. Possible side effects Side effects of Duphaston may include gastro-intestinal disturbances allergic skin rashes or urticaria changes in libido acne fluid retention mass gain mental depression and breast changes which may include discomfort or gynaecomastia. Alterations in liver function tests have been reported and less frequently jaundice. In a small percentage of the treated cases breakthrough bleeding may occur which can be prevented by increasing the dosage. During the clinical application of Duphaston no virilising side effects were observed. If you take too much See "Possible side effects" and "Cautions". Treatment is symptomatic and supportive. Drug interactions Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.

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Women's Health: Aygestin (Norethindrone Acetate) Aygestin (Norethindrone Acetate) is a progestin used to treat endometriosis a disorder of the lining of the uterus. It may also be used to treat menstrual disorders and to treat other conditions as determined by your doctor. Buy Aygestin (Norethindrone Acetate) and other Women's Health products online at Medstore. About Aygestin (Norethindrone Acetate): Product Type: Women's Health Brand name: Aygestin Generic name: Norethindrone Acetate What is the most important information I should know about Aygestin? • Using Aygestin while you are pregnant can cause harm to the unborn baby. Do not use Aygestin if you are pregnant. Stop using the medication and tell your doctor if you become pregnant during treatment. • Avoid smoking cigarettes while taking Aygestin. Smoking increases your risk of developing a heart attack stroke or blood clot. • Aygestin does not protect you from sexually transmitted diseases — including HIV and AIDS. Using a condom is the only way to help protect yourself from these diseases. What is Aygestin? • Aygestin is a form of progesterone a female hormone. • Aygestin is used for birth control (contraception) to prevent pregnancy. Aygestin is also used to treat menstrual disorders endometriosis or abnormal vaginal bleeding caused by a hormone imbalance. • Aygestin may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before using Aygestin? • Aygestin is in the FDA pregnancy category X. This means that using the medication while you are pregnant can cause birth defects in the baby. Do not take Aygestin if you are pregnant. Stop taking the medication and tell your doctor if you become pregnant. If you plan to become pregnant after you stop taking Aygestin ask your doctor how long you should wait before trying to get pregnant. • You should not take Aygestin if you have: a history of stroke or blood clots; liver disease; a history of stroke or blood clots; cancer of the breast of ovary; unusual vaginal bleeding that a doctor has not diagnosed; or complications from a recent miscarriage or abortion. • Taking Aygestin may be dangerous if you have any of the conditions listed above. • Before taking Aygestin tell your doctor if you have: high blood pressure angina or heart disease; a bleeding disorder such as hemophilia; diabetes; high cholesterol; migraines; a history of depression or mental illness; asthma; or seizures or epilepsy. • If you have any of the conditions listed above you may not be able to use Aygestin or you may require a dosage adjustment or special monitoring during treatment. • This medication can pass into breast milk and may harm a nursing baby. Do not use Aygestin without telling your doctor if you are breast-feeding. • Taking Aygestin can cause you to have unusual results to certain medical tests. Tell any doctor who treats you that you are using Aygestin. How should I take Aygestin? • The dose schedule for Aygestin may be different for birth control than for treating other conditions. To best treat your condition Aygestin should be used exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended. Do not take Aygestin for longer than your doctor has prescribed. • Take the medication at the same time each dose day. Taking a pill late or missing a pill can increase your chances of having breakthrough bleeding or getting pregnant. • For birth control start a new pack of pills the day after your last pack is finished. 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Continue to take Aygestin and talk to your doctor if you experience: nausea; swollen or tender breasts; sleep problems (insomnia); depression mood swings; acne freckles or darkened skin areas; increased hair growth; weight gain or loss; or changes in your menstrual cycle or vaginal discharge. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Aygestin? • Before taking Aygestin tell your doctor if you are taking any of the following medicines: rifampin (Rifadin); phenytoin (Dilantin); carbamazepine (Tegretol); or a barbiturate such as amobarbital (Amytal) butabarbital (Butisol) mephobarbital (Mebaral) secobarbital (Seconal) or phenobarbital (Luminal Solfoton). • If you are using any of these drugs Aygestin may not work as well and you may get pregnant. You may need to use a second form of birth control if you are taking any of the medicines listed above. • There may be other drugs not listed that can affect Aygestin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. 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