Women's Health

Methotrexate

Women's Health » Cancer » Methotrexate

Methotrexate is an antimetabolite used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis. This medicine works by interfering with cell growth and by suppressing the immune system. Early treatment of rheumatoid arthritis with more aggressive therapy such as methotrexate helps to reduce further joint damage and to preserve joint function. This medicine may also be used to treat other conditions as determined by your doctor including lupus and psoriatic arthritis.

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About Methotrexate:

Product Type: Cancer

Brand name: Methotrexate What is methotrexate? Methotrexate interferes with the growth of certain cells of the body especially cells that reproduce quickly such as cancer cells bone marrow cells and skin cells. Methotrexate is used to treat certain types of cancer of the breast skin head and neck or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. Methotrexate may also be used for other purposes not listed in this medication guide. What is the most important information I should know about methotrexate? Methotrexate can cause serious or life-threatening side effects on your liver lungs kidneys and bone marrow (immune system). Do not take this medication in larger amounts or take it for longer than prescribed. Follow the directions on your prescription label. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have liver disease (especially if caused by alcoholism) a blood cell or bone marrow disorder or if you are breast-feeding a baby. This medication can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Use an effective form of birth control whether you are a man or a woman. Tell your doctor if you or your sexual partner become pregnant during treatment. To be sure this medication is not causing harmful effects your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments. There are many other medicines that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. What should I discuss with my healthcare provider before taking methotrexate? Do not use this medication if you are allergic to methotrexate. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have: • liver disease; • alcoholism or cirrhosis of the liver; • a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells); • a bone marrow disorder; or • if you are breast-feeding a baby. Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you. Before using methotrexate tell your doctor if you are allergic to any drugs or if you have: • kidney disease; • liver disease; • lung disease or pneumonia; • stomach ulcers; • any type of infection; or • if you are receiving radiation treatments. FDA pregnancy category X. Methotrexate can cause birth defects in an unborn baby. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use birth control to prevent pregnancy while you are using methotrexate whether you are a man or a woman. Methotrexate use by either parent may cause birth defects. Before you start taking methotrexate your doctor may want you to have a pregnancy test to make sure you are not pregnant. If you are a man use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends. If you are a woman use an effective form of birth control while you are taking methotrexate and for at least one cycle of ovulation after your treatment ends. Do not give this medicine to a child without the advice of a doctor. Older adults may be more likely to have side effects from this medication. How should I take methotrexate? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Follow the directions on your prescription label. You must use the correct dose of methotrexate for your condition. The medication is sometimes taken only once per week. Some people have died after taking methotrexate every day by accident. Ask your doctor if you have any questions about your dose of methotrexate or how often to take it. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions. It is important to use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. To be sure this medication is not causing harmful effects your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested and you may need an occasional liver biopsy. Do not miss any scheduled appointments. Store methotrexate at room temperature away from moisture and heat. What happens if I miss a dose? Call your doctor if you miss a dose of methotrexate. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal. Overdose symptoms may include pale skin easy bruising or bleeding unusual weakness mouth sores nausea vomiting black or bloody stools coughing up blood or vomit that looks like coffee grounds and urinating less than usual or not at all. What should I avoid while taking methotrexate? Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) especially if you are being treated for psoriasis. Methotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen. Avoid drinking alcohol while taking methotrexate. Methotrexate side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Stop using methotrexate and call your doctor at once if you have any of these serious side effects: • dry cough shortness of breath; • diarrhea vomiting white patches or sores inside your mouth or on your lips; • blood in your urine or stools; • urinating less than usual or not at all; • fever chills body aches flu symptoms; • sore throat and headache with a severe blistering peeling and red skin rash; • pale skin easy bruising or bleeding weakness; or • nausea stomach pain low fever loss of appetite dark urine clay-colored stools jaundice (yellowing of the skin or eyes). Less serious side effects may include: • nausea vomiting upset stomach; • dizziness tired feeling; • headache; • bleeding of your gums; or • blurred vision. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. What other drugs will affect methotrexate? Before taking methotrexate tell your doctor if you are using any of the following drugs: • azathioprine (Imuran); • chloramphenicol (Chloromycetin); • hydroxychloroquine (Plaquenil Quineprox); • retinol tretinoin (Retin-A) isotretinoin (Accutane); • steroids (prednisone and others); • sulfa drugs such as Azulfidine Bactrim or Septra; • phenytoin (Dilantin); • probenecid (Benemid); • tetracycline (Brodspec Panmycin Sumycin Tetracap); • theophylline (Elixophyllin Slo-Bid Theobid Theo-Dur); • gold treatments such as auranofin (Ridura) or aurothioglucose (Solganol); • oral diabetes medications such as acetohexamide (Dymelor) chlorpropamide (Diabinese) glipizide (Glucotrol) glimepiride (Amaryl) or tolbutamide (Orinase); • penicillin antibiotic such as ampicillin (Principen) amoxicillin (Amoxil Trimox) carbenicillin (Geocillin) cloxacillin (Cloxapen) dicloxacillin (Dynapen) nafcillin (Unipen) oxacillin (Bactocill) penicillamine (Cuprimine Depen) or Bee-Pen Pen-Vee K Veetids; • salicylates such as aspirin Disalcid Doan's Pills Dolobid Salflex Tricosal and others; or • NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin Advil) naproxen (Aleve Naprosyn) diclofenac (Voltaren) diflunisal (Dolobid) etodolac (Lodine) flurbiprofen (Ansaid) indomethacin (Indocin) ketoprofen (Orudis) ketorolac (Toradol) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) piroxicam (Feldene) and others. This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Women's Health: Aygestin (Norethindrone Acetate) Aygestin (Norethindrone Acetate) is a progestin used to treat endometriosis a disorder of the lining of the uterus. It may also be used to treat menstrual disorders and to treat other conditions as determined by your doctor. Buy Aygestin (Norethindrone Acetate) and other Women's Health products online at Medstore. About Aygestin (Norethindrone Acetate): Product Type: Women's Health Brand name: Aygestin Generic name: Norethindrone Acetate What is the most important information I should know about Aygestin? • Using Aygestin while you are pregnant can cause harm to the unborn baby. Do not use Aygestin if you are pregnant. Stop using the medication and tell your doctor if you become pregnant during treatment. • Avoid smoking cigarettes while taking Aygestin. Smoking increases your risk of developing a heart attack stroke or blood clot. • Aygestin does not protect you from sexually transmitted diseases — including HIV and AIDS. Using a condom is the only way to help protect yourself from these diseases. What is Aygestin? • Aygestin is a form of progesterone a female hormone. • Aygestin is used for birth control (contraception) to prevent pregnancy. Aygestin is also used to treat menstrual disorders endometriosis or abnormal vaginal bleeding caused by a hormone imbalance. • Aygestin may also be used for purposes other than those listed in this medication guide. What should I discuss with my healthcare provider before using Aygestin? • Aygestin is in the FDA pregnancy category X. This means that using the medication while you are pregnant can cause birth defects in the baby. Do not take Aygestin if you are pregnant. Stop taking the medication and tell your doctor if you become pregnant. 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Do not use Aygestin without telling your doctor if you are breast-feeding. • Taking Aygestin can cause you to have unusual results to certain medical tests. Tell any doctor who treats you that you are using Aygestin. How should I take Aygestin? • The dose schedule for Aygestin may be different for birth control than for treating other conditions. To best treat your condition Aygestin should be used exactly as your doctor has prescribed it for you. Do not use more of the medication than recommended. Do not take Aygestin for longer than your doctor has prescribed. • Take the medication at the same time each dose day. Taking a pill late or missing a pill can increase your chances of having breakthrough bleeding or getting pregnant. • For birth control start a new pack of pills the day after your last pack is finished. There is no break between packs. • If you vomit soon after taking Aygestin use a backup method of birth control (such as a condom and/ or spermicide) for 48 hours. • You may have some light bleeding or spotting between periods. Continue taking Aygestin even if this occurs. • If your menstrual period is late you may be pregnant. If it has been more than 45 says since the start of your last period call your doctor or use a home pregnancy test. • You will need to have yearly physical exams and Pap smears while you are using Aygestin. Examine your breasts at home every month to check for lumps. It is important that you not miss any scheduled visits to your doctor. • After you stop using Aygestin you may start bleeding within a few days. • Store Aygestin at room temperature away from moisture and heat. What happens if I miss a dose? • Take the missed dose as soon as you remember. Then take the next dose at your regularly scheduled time. Do not take extra medicine to make up the missed dose. • If you were more than 3 hours late in taking your dose use a backup method of birth control (such as a condom and/ or spermicide). Keep using the backup method for at least 48 hours to ensure protection from pregnancy. • If you are not sure what to do about a missed dose keep taking Aygestin and use a backup method of birth control until you can talk to your doctor. What happens if I overdose? • An overdose of Aygestin is not likely to cause serious overdose symptoms. Call your doctor if you think you have used too much of this medicine. • Symptoms of a Aygestin overdose have not been reported. What should I avoid while taking Aygestin? • Women who use hormone medication should not smoke. Smoking will increase your risk of having a serious side effect from Aygestin such as heart attack stroke or a blood clot. • Aygestin does not protect you from sexually transmitted diseases — including HIV and AIDS. 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Continue to take Aygestin and talk to your doctor if you experience: nausea; swollen or tender breasts; sleep problems (insomnia); depression mood swings; acne freckles or darkened skin areas; increased hair growth; weight gain or loss; or changes in your menstrual cycle or vaginal discharge. • Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect Aygestin? • Before taking Aygestin tell your doctor if you are taking any of the following medicines: rifampin (Rifadin); phenytoin (Dilantin); carbamazepine (Tegretol); or a barbiturate such as amobarbital (Amytal) butabarbital (Butisol) mephobarbital (Mebaral) secobarbital (Seconal) or phenobarbital (Luminal Solfoton). • If you are using any of these drugs Aygestin may not work as well and you may get pregnant. You may need to use a second form of birth control if you are taking any of the medicines listed above. • There may be other drugs not listed that can affect Aygestin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. 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